OC34 - CALCIUM SUPPLEMENTS WITH VITAMIN D DO NOT INCREASE RISK OF CARDIOVASCULAR DISEASES: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL
L. Rejnmark1,*, P. Vestergaard1, L. Mosekilde1
1 Dept of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Abstract: Recent studies have suggested an increased risk of myocardial infarctions in users of calcium supplements, but it is unclear whether a similar increased risk applies if calcium is co-administrated with vitamin D (CaD).
In the Randers City Study, 9505 subjects above the age of 66 (median 73) years were block randomized to a daily supplement with 1000 mg of elementary calcium in combination with 10 microgram of cholecalciferol (n=4957) or no treatment (n=4648) for 3.5 years. Using data from our nation-wide computerized hospital discharge register, we analyzed risk of death, myocardial infarctions (MI), and cardiovascular diseases (CVD) in terms of heart failure, angina or MI according to treatment allocation (intention to treat analysis). We calculated Hazard Ratio (HR) with 95% confidence intervals (95%CI) using Cox Regression analysis.
During the 3.5 years of treatment, 345 participants sustained an incident MI. Risk was significantly increased in men compared with women (MI: HR 2.05; 95%CI 1.66-2.45), in subjects with prior CVD (HR 5.66; 95%CI 4.41-7.26), and increased with advanced age (per decade HR 1.25; 95%CI, 1.09-1.44) Compared with the controls, risk of MI was not increased in the group of participants randomized to CaD (HR 0.97; 95% CI, 0.79–1.20). Adjustment for age, gender, and prior CVD showed similar risk estimates. Similarly, extending the analyses to include all participants with an incident episode of CVD (n=1003 subjects) did not show effects of supplementation with CaD (HRadj 0.99; 95%CI, 0.88-1.13). A total of 1678 participants died during study. Compared with no treatment, risk of death was not affected by CaD (HR 0.92; 95%CI, 0.84-1.02). However, accounting for CVD and death (combined endpoint: CVD or death, n=2283 participants) showed a significantly reduced risk in subjects randomized to CaD (HRadj 0.91; 95%CI, 0.84-0.99). No significant interaction terms were present with age, gender, or prior CVD.
In conclusion, supplementation with calcium in combination with vitamin D does not compromise cardiovascular health.
Disclosure of Interest: None Declared
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