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OC24 - LYCOPENE SUPPLEMENTATION IMPROVED BONE MINERAL DENSITY, BONE RESORPTION AND OXIDATIVE STRESS MARKERS IN POSTMENOPAUSAL WOMEN: THE CEOR STUDY

M.-S. M. Ardawi1,*, M. H. Qari2, A. A. Rouzi3, B. M. Mustafa3
1Department of Clinical Biochemistry, 2Department of Haematology, 3Department of Obstetrics and Gynecology, Center Of Excellence For Osteoporosis Research and Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract:
Background: Limited information is available on the role of lycopene, a potent antioxidant found mainly in tomatoes and its products, in bone loss and osteoporosis. We studied the effects of lycopene supplementation on bone mineral density (BMD), biochemical bone turnover (BTMs) and oxidative stress markers in postmenopausal women in a randomized controlled intervention study.

Methods: A total of 90 healthy women agreed to participate in the study and gave their informed consent. Inclusion criteria were: age of ≥ 50–65 years, postmenopausal state, independent mobility, and a femoral neck and/or lumbar spine (L1-L4) T-score values of ≥ 1.0. Women were excluded if they had cancer or chronic diseases or treatment for metabolic bone disorders or with diseases known to be associated with increased oxidative stress. Women were randomized into 3 equal groups to follow a daily lycopene (Lyc-O-mato) supplementation protocol: (1) 30 mg/day (n=30); (2) 45 mg/day (n=30); and (3) placebo capsules containing 0 mg/day lycopene (n=30). Following a 4-week washout period with no lycopene-containing foods were consumed, and at 2, 4 and 6 months of lycopene supplementation, fasting blood and second-void early morning urine samples were collected. Women were medically examined and data were collected on lifestyle, level of physical activity and submitted a 4-day dietary records. Lycopene, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), antioxidant enzymes, protein thiols, lipid peroxidation and BTMs (s-OC, s-PINP, s-bone ALP, s-CTX, u-NTX and s-TRACP-5b) were determined at various time intervals. BMD was measured by X-ray absorptiometry at baseline and 6 months following supplementation.

Results: Lycopene supplementation for 6 months significantly increased serum lycopene compared to placebo (P<0.001) and decreased bone resorption (P<0.001) with increases in bone formation markers (P<0.02). Lycopene supplementation significantly increased TAS (P<0.001) and decreased TOS (P<0.001); OSI (P < 0.001); lipid peroxidation (P<0.001) and protein oxidation (P<0.001) variables as compared with placebo control, respectively.

Conclusions: Our findings demonstrate positive effects of 6-months lycopene supplementation on decreasing bone resorption markers and oxidative stress variables in postmenopausal women: lycopene may be beneficial in decreasing the risk of bone loss and/or osteoporosis.

Disclosure of Interest: None Declared

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